The “-mab” family is used when receptor targets are overexpressed on the outside of cancer cells. Activate the body’s natural immune response.Deliver radioactive molecules or toxins to the inside of the cells through attachment to cellular receptors.Attach to receptors on the outside of cells to prevent the receptors from interacting with signaling molecules (e.g., growth factor receptors and growth factor interaction).The “-mab” family of targeted therapies has three distinct methods for interfering with cancer cell growth. Monoclonal antibodies end with the stem “-mab” and small molecule inhibitors end with the stem “-ib”. The ending letters (stem) of the generic names are like surnames that tell what family the drug is from and how the drug works to kill cancer cells. Presently, two main families of targeted therapies exist-monoclonal antibodies and small molecule inhibitors. In contrast to traditional chemotherapeutic agents that affect rapidly dividing cells, targeted agents are more precise in the way they fight cancer. Each generic name gives information on the what, how, and where of each particular drug. This is not the case with the family names of targeted cancer drugs. There may have been some family significance in the names, but it was hard to tell without knowing the family.
It was as if their parents purposefully decided to come up with the most unique names possible. I was reading through the program of my granddaughter's dance recital and noticed that there was not a single common name in the first three groups of young dancers.
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